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Lectures:Conserved molecular mechanisms regulating meiotic chromosome segregation in eukaryotes


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Presentation title:Conserved molecular mechanisms regulating meiotic chromosome segregation in eukaryotes

Time: 09:30 am, October 24, 2019

Place: D912, School of Food Science and Technology

Reporter: Prof.Yoshinori Watanabe

Brief introduction of presenter:

Professor Yoshinori Watanabe is a famous researcher in Molecular and Cellular Biosciences, he started his research at Tokyo University since 1990, he has published hundreds of high lever papers including cell, nature and science.At 2018, he joined the Francis Crick institute to continue his research. He was awarded 2006 Science Award from Japan Science and Technology Corporation (JST),2006 Japan Academy Medal, 2008 Kihara Memorial Prize for Science, 2010 Inoue Prize for Science, 2013 Uehara Prize, 2014 EMBO associate member, 2015 Takeda Medical Prize, 2016 Asahi Prize, 2016 Naito prize.


Abstract:

Chromosomes are segregated in all dividing eukaryotic cells and are the basis for genetic inheritance. In somatic cell division, replicated chromosomes are equally divided to daughter cells, whereas in germ cells chromosome numbers are reduced from diploid cells to produce haploid gametes. Over the last two decades, we have discovered key factors and mechanisms that regulate chromosome segregation in meiosis. In particular, we have found and characterized the Rec8 cohesin complex and its regulators shugoshin and meikin, which together play a central role in establishing reductional chromosome segregation in meiosis [1].  Our discovery that the Rec8 mutant causes the shift from reductional to equational division at meiosis I [2], has been applied to develop apomixis technology in crop species [3]. Thus, our findings are contributing to practical advances in agriculture and food production.

 

[1] Watanabe Y. Nat. Rev. Mol. Cell Biol. 13, 370-382 (2012)

[2] Watanabe Y, Nurse P Nature 400, 461-464 (1999)

[3] Wang C et al. Nat. Biotech. 37, 283-286 (2019)


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